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品牌： |
中间体 |
所在地： |
贵州 黔东南苗族侗族自治州 |
起订： |
≥1 kg |
供货总量： |
10000 kg |
有效期至： |
长期有效 |
分子式： |
C17H22ClNO3 |
分子量： |
323.8228 |
英文别名： |
SR-121463A 185913-79-5 |
详情介绍
SR-121463A 185913-79-5
价格:1000元/公斤 含量:99% 包装:25公斤
CAS;185913-79-5
分子式：C17H22ClNO3
分子量：323.8228
化学名称 N-tert-Butyl-4-[5'-ethoxy-4-[2-(4-morpholinyl)ethoxy]-2'-oxospiro[cyclohexane-1,3'-indolin]-1'-ylsulfonyl]-3-methoxybenzamide fumarate
The reduction of diethyl 3-(methoxymethoxy)glutarate (I) with LiAlH4 in THF gives 3-(methoxymethoxy)pentane-1,5-diol (II), which is treated with Ts-OH and TEA in THF to yield the disulfonate (III). The condensation of (III) with 5-ethoxyindolin-2-one (IV) by means of tBu-OK in THF affords the spiro compound (V), which is deprotected with HCl in methanol to afford the spiranic alcohol (VI). The oxidation of (VI) with pyridinium chlorochromate (PCC) over Al2O3 provides the spiranic cyclohexanone (VII), which is treated with 2-chloroethanol (VIII) and Ms-OH in toluene to give the ketal (IX). The reaction of (IX) with zinc borohydride and trimethylsilyl chloride in ethyl ether/dichloromethane yields the 2-chloroethoxy derivative (X), which is condensed with 4-(N-tert-butylcarbamoyl)-2-methoxybenzenesulfonyl chloride (XI) by means of tBu-OK in THF to afford the adduct (XII). Finally, the target compound is obtained by condensation of (XII) with morpholine (XIII) by means of NaI in DMF, followed by treatment with fumaric acid.
16359-54-9 C12H17ClN2 185913-79-5 C17H22ClNO3
402856-42-2 C17H23Cl2NO 65527-62-0 C21H27N3O
8378-23-2 C12H17NO 1099-87-2 C19H27NaO5S
99918-43-1 C11H18Cl2N2 1445566-01-7 C13H17NO
6740-85-8 C12H13ClO 1445583-20-9 C18H26N4O2
14461-91-7 C12H12N2O2 612526-40-6 C17H12BrFN4
39243-02-2 C16H12BrN5 40054-69-1 C17H15ClN4S
5650-44-2 C10H13NO 39742-60-4 C13H17NO
13956-29-1 C21H30O2 4021-34-5 C17H26N2O
2426-63-3 C17H27ClN2O 1364933-55-0 C23H22N2O
2894-68-0 C16H12Cl2N2O 39243-02-2 C16H12BrN5
67579-76-4 C18H26Cl2N2O 33643-46-8 C13H16ClNO
77872-41-4 C13H18N2O 28910-91-0 C17H12ClFN4
141-78-6 C4H8O2 87-90-1 C3Cl3N3O3
13415-55-9 C18H22O2 5485-65-4 C15H22ClNO
776994-64-0 C17H23NO3 21409-26-7 C19H24N2
13415-59-3 C16H24ClNO 2687-91-4 C6H11NO
79-41-4 C4H6O2 23022-83-5 C9H9BrO
2114-00-3 C9H9BrO 49656-78-2 C10H14ClNO
936-59-4 C9H9ClO 93-55-0 C9H10O
价格:1000元/公斤 含量:99% 包装:25公斤
CAS;185913-79-5
分子式：C17H22ClNO3
分子量：323.8228
化学名称 N-tert-Butyl-4-[5'-ethoxy-4-[2-(4-morpholinyl)ethoxy]-2'-oxospiro[cyclohexane-1,3'-indolin]-1'-ylsulfonyl]-3-methoxybenzamide fumarate
The reduction of diethyl 3-(methoxymethoxy)glutarate (I) with LiAlH4 in THF gives 3-(methoxymethoxy)pentane-1,5-diol (II), which is treated with Ts-OH and TEA in THF to yield the disulfonate (III). The condensation of (III) with 5-ethoxyindolin-2-one (IV) by means of tBu-OK in THF affords the spiro compound (V), which is deprotected with HCl in methanol to afford the spiranic alcohol (VI). The oxidation of (VI) with pyridinium chlorochromate (PCC) over Al2O3 provides the spiranic cyclohexanone (VII), which is treated with 2-chloroethanol (VIII) and Ms-OH in toluene to give the ketal (IX). The reaction of (IX) with zinc borohydride and trimethylsilyl chloride in ethyl ether/dichloromethane yields the 2-chloroethoxy derivative (X), which is condensed with 4-(N-tert-butylcarbamoyl)-2-methoxybenzenesulfonyl chloride (XI) by means of tBu-OK in THF to afford the adduct (XII). Finally, the target compound is obtained by condensation of (XII) with morpholine (XIII) by means of NaI in DMF, followed by treatment with fumaric acid.
16359-54-9 C12H17ClN2 185913-79-5 C17H22ClNO3
402856-42-2 C17H23Cl2NO 65527-62-0 C21H27N3O
8378-23-2 C12H17NO 1099-87-2 C19H27NaO5S
99918-43-1 C11H18Cl2N2 1445566-01-7 C13H17NO
6740-85-8 C12H13ClO 1445583-20-9 C18H26N4O2
14461-91-7 C12H12N2O2 612526-40-6 C17H12BrFN4
39243-02-2 C16H12BrN5 40054-69-1 C17H15ClN4S
5650-44-2 C10H13NO 39742-60-4 C13H17NO
13956-29-1 C21H30O2 4021-34-5 C17H26N2O
2426-63-3 C17H27ClN2O 1364933-55-0 C23H22N2O
2894-68-0 C16H12Cl2N2O 39243-02-2 C16H12BrN5
67579-76-4 C18H26Cl2N2O 33643-46-8 C13H16ClNO
77872-41-4 C13H18N2O 28910-91-0 C17H12ClFN4
141-78-6 C4H8O2 87-90-1 C3Cl3N3O3
13415-55-9 C18H22O2 5485-65-4 C15H22ClNO
776994-64-0 C17H23NO3 21409-26-7 C19H24N2
13415-59-3 C16H24ClNO 2687-91-4 C6H11NO
79-41-4 C4H6O2 23022-83-5 C9H9BrO
2114-00-3 C9H9BrO 49656-78-2 C10H14ClNO
936-59-4 C9H9ClO 93-55-0 C9H10O
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